Endocrine Abstracts

Background and Aim: Polycystic ovary syndrome (PCOS) is associated with compositional and functional alterations in gut microbiota. The cytokine interleukin-22 (IL-22) is produced by both innate and adaptive immune cells and closely linked to gut immunity. IL-22 is tightly controlled by its binding protein (IL-22BP), which serves as an antagonist of IL-22 signaling. Preliminary animal studies and limited human data in Asian populations suggest lower circulating levels of IL-22...

Background and Aim: Polycystic ovary syndrome (PCOS) is characterized by androgen excess and ovulatory dysfunction and appears to be associated with alterations in muscle mass and function. Combined oral contraceptives are commonly used for the long-term management of PCOS and their potential impact on muscle mass and strength remains unknown. This study aimed to assess whether oral contraceptive (OC) use along with general lifestyle advice would alter muscle mass and strength...